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Inovio Pharmaceuticals, Inc. (INO)

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[verwijderd] 2 februari 2011 11:49

novio Pharmaceuticals' Dual-Antigen SynCon™ DNA Vaccine for Prostate Cancer Induces Robust Responses in Preclinical Trial
Date : 02/02/2011 @ 4:00AM
Source : PR Newswire
Stock : Inovio (INO)
Quote : 1.29 0.02 (1.57%) @ 7:59PM

Inovio Pharmaceuticals' Dual-Antigen SynCon™ DNA Vaccine for Prostate Cancer Induces Robust Responses in Preclinical Trial
Inovio (AMEX:INO)
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Today : Wednesday 2 February 2011
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Inovio Pharmaceuticals, Inc. (NYSE Amex: INO), a leader in the development of therapeutic and preventive vaccines against cancers and infectious diseases, announced today the publication of a scientific paper in the journal Human Vaccines detailing potent immune responses in a preclinical study of Inovio's SynCon™ DNA vaccine for prostate cancer targeting two antigens. While current prostate cancer therapies target single antigens, in this study Inovio tested the hypothesis in mice that a broader collection of antigens, administered with Inovio's electroporation-based delivery technology, would improve the breadth and effectiveness of a prostate cancer immunotherapy.

(Logo: photos.prnewswire.com/prnh/20110127/L...

The development of a new treatment for prostate cancer would be a significant medical advance given that present treatment options (surgery, radiation and hormone deprivation), while somewhat effective, all carry deleterious side effects and often do not confer long-term cure. Across the United States, there were 218,000 new cases of prostate cancer and more than 32,000 deaths in 2010.

This study, conducted by Inovio scientists and their collaborators, is described in the published paper entitled, "Co-delivery of PSA and PSMA DNA vaccines with electroporation induces potent immune responses." The SynCon™ DNA vaccine evaluated in this study was generated by the creation of PSA and PSMA synthetic consensus immunogens based on human and macaque sequences, which enabled the amino acid sequences of the antigens to differ slightly from the native protein. In humans, this difference may aid in the evasion of self-tolerance while still mounting an anti-tumor immune response. Mice received two immunizations of highly optimized DNA vaccine delivered by electroporation. Immunogenicity was evaluated one week after the second vaccination. The resultant data showed the induction of strong PSA and PSMA-specific cellular immune responses and also significant antigen specific seroconversion, illustrating that both humoral and cellular immune responses can be generated by this approach.

Inovio previously collaborated with the UK's University of Southampton and Institute of Cancer Research in a study evaluating a DNA vaccine for prostate cancer delivered using Inovio's electroporation delivery technology. The published data from this phase I/II study of a DNA vaccine encoding for human PSMA generated proof-of-concept levels of both antibody and T-cell immune responses in the 30 patients vaccinated in this study.

These proof-of-concept results have recently been supported by positive immunology data from Inovio's phase I clinical study of its multi-antigen SynCon™ DNA vaccine against cervical dysplasias (VGX-3100). In this study, all three dose groups experienced significant antigen-specific antibody and T-cell immune responses against multiple antigens. In the third and final dose group, five of six (83%) patients developed the highest level of T-cell responses achieved by any non-replicating vaccine platform in patients to date.

Dr. J. Joseph Kim, Inovio's President and CEO, said: "This is an important study in which the first SynCon™ DNA vaccine against a cancer target was successfully tested. This immunotherapy targeting more than a single antigen as a treatment for prostate cancer generated strong antibody and T-cell immune responses, which are considered vital to addressing prostate cancer. Taken together with the previous preclinical and clinical data, the current published results support the advancement of this product into a Phase I clinical study."

Inovio's electroporation-based DNA vaccine delivery technology, employed in this study, involves the application of controlled, millisecond electrical pulses to create permeability in the cell membrane and enable dramatic uptake of the vaccine, which has been previously injected into local tissue. Inovio's electroporation-based DNA vaccine delivery systems can increase levels of gene expression (i.e. production of the immune-system-stimulating protein the vaccine was coded to produce) and immune responses of "naked" DNA vaccines by 100-fold or more.

About Inovio Pharmaceuticals, Inc.

Inovio is developing a new generation of vaccines, called DNA vaccines, to treat and prevent cancers and infectious diseases. These SynCon™ vaccines are designed to provide broad cross-strain protection against known as well as newly emergent strains of pathogens such as influenza. These vaccines, in combination with Inovio's proprietary electroporation delivery devices, have been shown to be safe and generate significant immune responses. Inovio's clinical programs include HPV/cervical dysplasia and cancer (therapeutic), avian flu (preventive), and HIV vaccines (both preventive and therapeutic). Inovio is developing universal influenza and other vaccines in collaboration with scientists from the University of Pennsylvania. Other partners and collaborators include Merck, National Cancer Institute, U.S. Military HIV Research Program, NIH, HIV Vaccines Trial Network, University of Southampton, and PATH Malaria Vaccine Initiative. More information is available at www.inovio.com.

[verwijderd] 2 februari 2011 13:00

deze kan ook weleens gek gaan doen vandaag.
bied 1,33 nu.... slot gister 1,29

[verwijderd] 2 februari 2011 13:05

bied 1,45

[verwijderd] 2 februari 2011 13:46

Haha koek heeft weer een aandeel gevonden ;) Je hebt gelijk deze kan vandaag wel is lekker gaan stijgen met zo bericht.

Sta je al in de rij om hem te bemachtigen?

[verwijderd] 2 februari 2011 13:49

ligt eraan hoever die stijgt in de pre markt.
maar met deze kan je goed traden vandaag verwacht ik.

[verwijderd] 2 februari 2011 13:55

1.49
Last Trade 0.20 (+15.5%)

[verwijderd] 2 februari 2011 13:58

Avg Vol (3 month)3: 554,342
Avg Vol (10 day)3: 401,614
Shares Outstanding5: 104.21M
Float: 83.75M
% Held by Insiders6: 15.46%
% Held by Institutions6: 9.20%
Shares Short (as of Jan 14, 2011)3: 2.64M

[verwijderd] 2 februari 2011 14:33

1.60 al in de pre markt.

welshterrier 5 2 februari 2011 14:38

Zoals ik het lees gaat het alleen over een publikatie in een blad?

[verwijderd] 2 februari 2011 14:44

quote:
welshterrier schreef op 2 februari 2011 14:38:
Zoals ik het lees gaat het alleen over een publikatie in een blad?

ja van de resultaten.die goed zijn :)

[verwijderd] 2 februari 2011 14:52

Nog even en ze stijgen gewoon al 40 a 50 % in de voorhandel ;)

[verwijderd] 5 augustus 2013 22:10

Nu begint het pas echt leuk te worden!

Gr

[verwijderd] 6 augustus 2013 13:33

Helemaal geen trading aandeel. Gaat gewoon omhoog.
Dit kan alleen als een grote partij aan het inkopen is.
Vandaag premarket al 5% omhoog.
Mooi zo.

[verwijderd] 6 augustus 2013 14:51

quote:
Pana schreef op 6 augustus 2013 13:33:
Helemaal geen trading aandeel. Gaat gewoon omhoog.
Dit kan alleen als een grote partij aan het inkopen is.
Vandaag premarket al 5% omhoog.
Mooi zo.

8% tot 12% in de min bij de sluit .. denk ik

[verwijderd] 6 augustus 2013 17:56

Gezien de stijging gisteren valt dat nog mee.
Aandeel vertoont wel veerkracht.
Maar wat een omzet.

[verwijderd] 7 augustus 2013 09:04

quote:
Pana schreef op 6 augustus 2013 17:56:
Gezien de stijging gisteren valt dat nog mee.
Aandeel vertoont wel veerkracht.
Maar wat een omzet.

Gisteren aardig omlaag, ook nabeurs. INO gaf aan niet te reageren op markt geruchten/wilde schommelingen van de koers.

Omzet erg hoog, uitzonderlijk voor dit aandeel!

gr

[verwijderd] 7 augustus 2013 09:38

quote:
mvdh schreef op 7 augustus 2013 09:04:
[...]

Gisteren aardig omlaag, ook nabeurs. INO gaf aan niet te reageren op markt geruchten/wilde schommelingen van de koers.

Omzet erg hoog, uitzonderlijk voor dit aandeel!

gr

2.30 lijkt de nieuwe bodem te worden. tikte ino intraday ook al even aan. (nog) geen positie.

[verwijderd] 20 augustus 2013 17:46

deze zakt toch ook weer heel snel terug

[verwijderd] 21 augustus 2013 16:23

flinke stijging zeg.

[verwijderd] 6 september 2013 21:11

Gaat erg leuk door

Ber

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