Kleintje66 schreef op 17 maart 2021 13:17:
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Als er iets niet twijfelachtig is is het het middel, de enorme hoeveelheid onderzoeken die het effect bewijzen is aanwezig.
www.sciencedirect.com/topics/neurosci...www.ncbi.nlm.nih.gov/pmc/articles/PMC..."Since VIP contributes to important physiological functions including anion secretion, the regulation of permeability of epithelial tight junctions, mucosal inflammation, glycemic control, Th1–Th2 balance, and tumor growth, VIP has been suggested to be a therapeutic target for diseases such as diarrhea 58, IBD 95, diabetes 28, autoimmune diseases 115, neurodegenerative disorders 116, lung disease 117, 118, sarcoidosis 119, and cancers 114. Although VIP has well-studied anti-inflammatory and other therapeutic potential, VIP-based drug design has not been entirely successful because rapid degradation of the peptide limits its bioavailability and delivery. Furthermore, multiple cellular targets that bind VIP at high affinity may cause undesirable adverse effects. Therefore, synthesis of a stable VIP analog, or the targeted delivery of VIP or its analogs via nanoparticles are desirable options.
Recent advances in the field include the synthesis of stable analogs such as lipophilic or peptide VIP derivatives that mimic the activity of native VIP 120. Another strategy is VIP self-associated with sterically stabilized micelles, which protects VIP from degradation and inactivation 115. Injection of VIP-induced regulatory dendritic cells ameliorates TNBS-induced colitis models in mice 95. VIP gene transfer using lentivirus is also useful to induce immunosuppression in the murine arthritis model 121. Finally, VIP-tagged nanoparticles may be a useful strategy for selective drug delivery to VPAC-overexpressing tumor cells and immune cells 114, 122"
Geeft verder niet dat je te weinig tijd hebt om uit te zoeken hoe de zaken echt liggen, vandaar dat je niet weet waarom de oude onderzoeken niet verder zijn gekomen en er nu enorme kansen liggen voor het bedrijf dat het effect kan omzetten in een bewezen medicijn.