moaventtoch schreef op 28 mei 2020 12:25:
[...]
conclusie.
Unlike all currently prevailing hypotheses, which focus on non-pathogenspecific mechanisms, we propose a pathogen-specific mechanism by which
non-structural SARS-CoV proteins bind to C1 esterase inhibitor (C1-INH,
encoded by SERPING1), potentially causing a deficiency in this regulator of the
contact and complement systems. Although it requires experimental
confirmation, such as protein-protein binding and C1-INH enzymatic assays, the
plausibility of our hypothesis is supported by the multiplicity of interactions
observed between CoV proteins and C1-INH. Importantly, our hypothesis
provides a single mechanism that explains many clinical, pathological and
laboratory findings associated with severe COVID-19 and opens up a whole
new set of therapeutic options to tackle the most deadly manifestations of this
viral disease